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Growth · Software Engineer Interview Guide

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How to Pass the Exscientia Software Engineer Interview in 2026

The Exscientia DNA (TL;DR)

Exscientia seeks candidates who demonstrate strong scientific acumen, particularly in AI/ML applied to drug discovery. They value interdisciplinary problem-solving, the ability to translate complex biological/chemical challenges into computational solutions, and a collaborative mindset for innovation.

The Exscientia Interview Loop

Your onsite loop will typically consist of 5 rounds.

  1. 1

    Round 1

    Recruiter Screen
    Motivation, role fit, logistics.
  2. 2

    Round 2

    Coding Screen
    LeetCode-medium algorithmic problems under time pressure.
  3. 3

    Round 3

    System Design
    Distributed systems, trade-offs at scale, architecture under constraints.
  4. 4

    Round 4

    Onsite Coding
    LeetCode-hard, debugging, code clarity, edge cases.
  5. 5

    Round 5

    Behavioral / Leadership
    Past evidence of ownership, influence, resolving conflict.

The Danger Zone: Top Reasons Candidates Fail

Based on our database of Exscientia interview outcomes, avoid these common traps:

  • Lack of a plan for monitoring performance and identifying bottlenecks.
  • Not clearly articulating their specific role and contribution.
  • Inefficient sorting or selection algorithms leading to poor performance on large datasets.
  • Inefficient grouping of data, leading to repeated calculations.

Test Yourself: Real Exscientia Questions

Three real prompts pulled from our database.

Type · Algorithmic Problem

You are given a graph representing molecular interactions. Design an algorithm to find the shortest path between two specific molecules, where path length is defined by a weighted sum of interaction strengths. Some interactions might be inhibitory.

Type · API Design

Design an API for a system that predicts the properties of novel molecules based on their chemical structure. Consider how to handle potentially long-running prediction jobs, versioning, and authentication.

Type · Learning & Adaptability

Tell me about a time you had to quickly learn a new technology or domain to complete a project. How did you approach the learning process, and what did you learn beyond the specific technology?

+ many more questions, signals, and worked examples

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Exscientia Interview Question Bank

A sample from our database, grouped by round. Sign up to see the full set.

9 of 14 questions shown

1

Recruiter Screen

1
  1. 1

    Type · Motivation

    What interests you about working at Exscientia, and how do you see your skills contributing to our mission of discovering and developing novel medicines?
2

Coding Screen

3
  1. 2

    Type · Data Structures & Algorithms

    Given a dataset of patient responses to different drug candidates, write a function to identify the top K most effective drug candidates for a specific patient profile, considering various efficacy metrics. Assume the dataset can be very large.
  2. 3

    Type · Algorithmic Problem

    You are given a graph representing molecular interactions. Design an algorithm to find the shortest path between two specific molecules, where path length is defined by a weighted sum of interaction strengths. Some interactions might be inhibitory.
  3. + 1 more questions in this round (sign up to unlock)
3

System Design

3
  1. 4

    Type · API Design

    Design an API for a system that predicts the properties of novel molecules based on their chemical structure. Consider how to handle potentially long-running prediction jobs, versioning, and authentication.
  2. 5

    Type · Data Pipeline

    Design a data pipeline to ingest, process, and store large volumes of high-throughput screening (HTS) data from various lab instruments. The pipeline needs to be fault-tolerant and support near real-time analysis.
  3. + 1 more questions in this round (sign up to unlock)
4

Onsite Coding

3
  1. 6

    Type · Algorithm - Hard

    Implement a function to find the optimal sequence of chemical reactions to synthesize a target molecule, given a library of possible reactions and starting materials. This is analogous to finding a path in a large, potentially cyclic state space graph.
  2. 7

    Type · Debugging

    Here is a piece of code that calculates the binding affinity of a drug candidate to a protein. It's producing incorrect results for certain inputs. Debug this code and explain your process.
  3. + 1 more questions in this round (sign up to unlock)
5

Behavioral / Leadership

4
  1. 8

    Type · Collaboration

    Tell me about a time you had to collaborate with scientists or researchers who had a very different technical background than yours. How did you ensure effective communication and achieve a common goal?
  2. 9

    Type · Technical Challenge

    Describe a technically challenging problem you faced in a previous project related to data processing, simulation, or machine learning in a scientific context. What was your approach to solving it, and what was the outcome?
  3. + 2 more questions in this round (sign up to unlock)

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Interview tracks at Exscientia

How Exscientia's DNA translates across functions. Pick your role.

SWE roles at Exscientia demand robust CS fundamentals, proficiency in ML frameworks (e.g., PyTorch) and scientific computing. Expect to be evaluated on designing scalable data pipelines for biological data, MLOps for drug discovery, and building robust, high-performance computational platforms.

Algorithmic Problem

You are given a graph representing molecular interactions. Design an algorithm to find the shortest path between two specific molecules, where path length is defined by a weighted sum of interaction strengths. Some interactions might be inhibitory.

API Design

Design an API for a system that predicts the properties of novel molecules based on their chemical structure. Consider how to handle potentially long-running prediction jobs, versioning, and authentication.

+ 1 more

Unlock the Software Engineer grading rubric for Exscientia

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Compare Exscientia with similar employers

Same DNA, different bar. Browse the closest companies in our database and see how their loops differ.

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